Mangroves are the only trees that are capable of thriving in salt water. Mangroves are biochemically unique, producing a wide array of novel natural products. In this present study antimicrobial activity of Rhizophora mucronata (Rhizophoraceae) and Acanthus ilicifolius (Acanthaceae) the plant parts of were collected from Kakinada, Godavari-krishna delta and other areas of Andhra Pradesh were dried and extracted successively with hexane, chloroform and methanol using the soxhlet extraction apparatus. The antimicrobial activities of the organic solvent extracts on the various test microorganisms, including bacteria and fungi investigated using agar well diffusion technique. This study, has to some extent, validated the potential of the mangrove plants against phytopathogens.