NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In silico proteomics study of NF- κB was conducted to find out the similarities and differences between sequences from different mammals. And also to find out the functional sites, physico chemical parameters, domains, secondary and tertiary structures of the protein. Hence, the study conducted will give insight regarding the function and components of NF-κB sequences from different mammals taken for the research activity.
