The present study is aimed to evaluate the In-silico docking analysis of the compounds identified from the leaves of Orthosiphon stamineus for the Nephroprotective activity. Captopril is used as a standard and it is well-known for the Nephroprotective activity by inhibiting the enzyme known as Angiotensin Converting Enzyme (ACE). Compound 1- Eupatorin, Compound 2- Rosmarinic acid, Compound 3- Orthosiphol A, Compound 4- Sinenstein , Compound 7- 5-Hydroxy- 6,7,3,4-tetramethoxyflavone identified from the leaves of Orthosiphon stamineus have shown significant ACE receptor inhibitory activity. Of the 5 compounds Eupatorin (compound 1), Rosmarinic acid (compound 4) showed maximum ACE Receptor inhibition than the standard drug Captopril and have shown excellent Nephroprotective activity with better ADMET profiles.
