Famotidine (FAMO), an antiulcer drug, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve dissolution rate and solubility of the drug, hydrotrophism technique was employed. The formulations were to be formed with the two hydrotropic agents (Urea and Sodium citrate) with three ratios (1:2, 1:4, 1:6). Formulations so prepared were characterised by drug content study, solubility study, In-Vitro dissolution study, differential scanning calorimetry (DSC) and X-Ray powder diffractometry (XRD). All carriers show improvement in the dissolution rate of the drug. The DSC studies show change in the polymorphism in most of the formulations. The XRD studies of the formulations show no change in their crystalline form. The formulation containing Urea & sodium citrate as drug carrier show better solubility and dissolution rate with comparison to pure drug confirming the improved solubilization of this drug.
