The purpose of the present study was to study the impact of superdisintegrant on the release of Oro-Dispersible Tablet containing Losartan Potassium as a model drug using Natural and Synthetic Superdisintegrants. Various formulations were prepared by direct compression using different concentrations of natural superdisintegrant, Husk of Plantago ovata and synthetic superdisintegrants namely Kyron T-314, and croscarmellose sodium. The blends were evaluated for additive properties. Prepared tablets were evaluated for physical parameters and in vitro drug release. Dissolution profile suggested that tablet prepared with Plantago ovata husk and Kyron T-314 were capable of releasing up to 99 % drug within 15 minutes in phosphate buffer 6.8 pH, by an appropriate combination of excipients it is thus possible to obtain Oro-Dispersible Tablets using simple and conventional technique.
