Traditional and folklore medication systems play important role in the maintenance of health around the globe. The rational design of novel drugs from traditional medicines offer new prospects for modern health-care. Cow-urine has been used from ancient times for curing many ailments of human beings. The aim of present study was to evaluate the whole freeze dried cow urine and the fractions of cow urine for their immunomodulatory potential in rats, using Delayed type hypersensitivity reaction, Neutrophil adhesion test, Hematological parameters like RBC, WBC counts and Carbon clearance test for phagocytic index. As per findings freeze dried cow urine exhibited better effect on immune system compared to methanol, ethyl acetate, aqueous and acetone fractions of cow-urine.
