Survey was focused exclusively on human excreta and sera for microsporidium and hepatitis- B.The immune profile was determined of HIV+ individuals in Benue State. Intestinal epithelium was the most prevalent site of human microsporidium infection, 54 (4.2%) were infected in both sexes. Enterocytozoon bieneusi was most prevalent in Makurdi with no significant relevance in the spread of microsporidium species among a cohort population study (r=0.79 >0.60, df=9). Urinary tract microsporidiosis appears in 31(2.4%) patients with Encephalitozoon cuniculi although, many persons during these findings do not have symptoms referable to the urogenital route and 9(1.3%) were HBsAg+ with no significant difference since r=0.76>0.75, df=6. Stools were loose to watery and co- infected with laboratory evidence for intestinal microsporidium in 1(0.5%) with T-cells < 80 cell/μl. However, sexual transmission of microsporidiosis cannot be excluded. Therefore, the clinical spectrum of the disease should be tied to thorough laboratory investigation and strict hygienic condition should be maintained.
