Aim of the study: Murraya koenigii (MK), an aromatic perennial shrub known as ‘Curry patta’ in India. Literature review suggests that root of this plant is used as purgative, stimulant and for general body aches apart from various medicinal uses of leaves of this plant. In this context, the standardized methanol, aqueous and petroleum ether extracts of roots of MK to total phenolic content is hypothesized for the evaluation of the hypoglycemic activity. Material and Methods: Inbreed adult male Charles-Foster (CF) albino rats were used in the experiment. The suspension of standardized methanol (ME), aqueous (AE) and petroleum ether (PEE) to total phenolic content were treated for hypoglycemic activity in oral glucose tolerance test (OGTT) method, normoglycemic and alloxan-induced diabetic rats. Results: The ME (200 mg/kg and 400 mg/kg) showed potential hypoglycemic activity in normoglycemic and diabetic rats, and further in OGTT method. Furthermore, ME showed significant (P<0.05) increase in final body weight, total hemoglobin, insulin, albumin and high density lipoprotein levels, however, decrease in fluid intake, glycosylated hemoglobin, urea, creatinine, total cholesterol, triglyceride and low density lipoprotein levels. Moreover, it mitigated the liver function in terms of reducing serum glutamate oxaloacetate transaminases, serum glutamate pyruvate transaminases and alkaline phosphatase activity. Additionally, it improved oxidative stress in terms of reducing lipid peroxidase and superoxide dismutase, and elevating catalase activity. Conclusions: These findings suggest that the ME found to be potential hypoglycemic compared to AE and PEE, and would be a promising candidate for the treatment of diabetes.
