The preliminary phytochemical screening of methanolic extract of Chrysanthellum indicum revealed the presences of alkaloids, flavonoids, saponins, steroid, terpenoids and tannins. Also the LD50 of the extract is found to be 1131.4 mg/kg intraperitoneal. The effect of the methanolic extract on blood glucose levels of alloxan induced diabetes in Wistar rats was also investigated. Three doses of the extract (100, 200 and 400 mg/Kg) were administered intraperitoneally. The three doses administered there was no significant difference at 1 day of extract administration when compared to negative control. However, after 3, 5,7 and 9 days of extract administration there was a significant (p<0.05) decrease in blood glucose levels in all the three doses administered when compared to negative control (normal saline). As regard to the positive control (metformin) there was a significant (P<0.05) in the blood glucose levels when compared to negative control (normal saline). In conclusion, the three doses of the extract administered shown both significant (p<0.05) hypoglycemic and anti-hyperglycemic effects in Wistar rats.
