This study focuses on the histopathology and biochemical effects of excess high dose of methionine in rabbits. Two groups of 30 rabbits were tested by some experiments: the first group(control group) was given a commercial diet; and the second group(care group) was also given an experimental diet containing 1.2% methionine by weight in the diet for 3 months. In all of the rabbit species mentioned above blood was obtained via samples by their marginal ear veins throughout 10,20,30,40,50,60,70,80 and 90 days, respectively. On necropsy, the liver, kidney and heart samples of 5 cases out of 10 rabbits of the first group and 10 cases out of 20 of the second group were taken at the end of the second and third month. In addition, pathologic lesion on the liver and kidney after two months was observed, so that cases were developed in a three month period. Eventually, the biochemical parameters confirmed the histopathology results; deity excess methionine causes a toxic effect on liver, kidney and heart tissues.
