Significant increase in the histochemical parameters and serum variables was observed in the pan masala treated mice. The target organs in the present study were liver, kidney and testes which all showed severe damage as observed by the abnormal rise in Acid phosphatase, Alkaline phosphatase and Lactate dehydrogenase activity. The level of GOT and GPT was measured in liver as well as serum where its elevated value marked liver impairement. There was a significant rise in serum protein, calcium, triglyceride, glucose and creatinine after 36 weeks exposure of pan masala in Swiss mice. Elettaria cardamomum (L.) Maton showed a promising effect by lowering down the elevated abnormal rise in enzymatic activity and serum parameters
