The aim of the present study was to evaluate the hepatoprotective effect of Prunus persica leaves extract against carbon tetrachloride induced hepatic injury in rats. Animals in Group I served as normal control (distilled water) group, Group II served as toxic control (CCl4 treated ) group, Group III served as standard (Silymarin) group, and Group IV, V served as ( 200 & 400 mg/kg bw, p.o) Prunus persica leaves extract treated groups respectively. The levels of the serum biomarkers such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin, albumin & total protein were significantly increased in CCl4 treated rats when compared with the normal control group but the rats treated with Prunus persica leaves extract (200 mg/kg ) showed decrease in SGOT (250.5±4.43), SGPT (176.4±5.20), ALP (242.43±6.30), bilirubin (2.20±0.05) level and increase in serum albumin (3.20±0.05) and total protein (3.81±0.07) level as compared to that of toxic control group. The rats pre administered with ethanolic extract, 400 mg/kg (Group V) showed the more decrease in levels of SGOT (208.4±5.52), SGPT (95.63±5.30), ALP (204.41±5.03), bilirubin (1.76±0.02) level and increase in serum albumin (3.99±0.06) and total protein (4.69±0.08) level when compared to that of toxic control group. On the basis of results obtained, it can be concluded that the ethanolic extract of Prunus persica leaves seems to have hepatoprotective activity which may be due to the presence of flavonoids.
