European Journal of Zoological Research
Abstract
Author(s): Rafi Khan.P., Aleemuddin.M.A., K.Sravani and K.Sivarama Krishna
In the present study protective effect of coldeniaprocumbens hydroalcoholic extract on acetaminophen induced
hepatotoxicity on albino wistar ratswas evaluated. Acetaminophen at the dose of 750mg/kgproduce hepatotoxicity
as manifested by the significant rise of Serum glutamate pyruvate transaminase (SGPT), serum glutamate
oxaloacetate transaminase (SGOT)and ALP activities were significantly (p < 0.05) elevated in the acetaminophen
alone treated animals and decrease in total proteins levels. Pretreatment with coldeniaprocumbens hydro alcoholic
extract (100 mg and 200mg) siginificantly(P<0.05) decrease the SGPT, SGOT, ALP and increase in total proteins.
The antioxidant studies reveals that the levels of hepatic superoxide dismutase (SOD), catalase (CAT), glutathione
peroxidase and glutathione-S-transferase (GST),reduced glutathione (GSH) wereincreased inAPAP treated animals
with significantly reduced in malondialdehyde(MDA) content, which is reversed in pretreatment with
hydroalchoholic extract of coldeniaprocumbens. Inconclusion the protective effect of coldeniaprocumbens against
acetaminophen-inducedacute toxicity is mediated either by preventing the decreasing the of hepatic antioxidant
status or due to its direct radical scavenging capacity.
