The roots of Pergularia daemia and Carissa carandas have used to treat liver disease and jaundice among the herbal practitioners of Western Ghats Tamilnadu, India.The present study is to evaluate the hepatoprotective effects of the ethanol and aqueous extracts of roots of Pergularia daemia and Carissa carandas were against ethanol induced hepatotoxicity in rats. The hepatotoxic of ethanol and the hepatoprotective effects of ethanol and aqueous extracts of roots of P. daemia (PDEE & PDAE) and C. carandas (CCEE & CCAE) were estimated their liver function test, serum lipid profile, levels of lipid peroxidation and the activity of liver antioxidant enzyme glutathione. The PDEE, PDAE, CCEE and CCAE at a dose level of 100 mg/kg and 200 mg/kg produce significant hepatoprotection by decreasing serum transaminase (SGPT & SGOT), alkaline phosphate, bilirubin and lipid peroxidation, while significantly increased the levels of liver glutathione and serum protein. The effects of PDEE, PDAE, CCEE and CCAE were comparable with standard drug silymarin.
