The aim of this study was to investigate the hepatoprotective activity of methanolic extracts of Limnophilla indica against CCl4 induced hepatotoxicity in rats. Silymarin was used as standard drug. These chemical’s are well-known hepatotoxin, when exposure to these chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Animals were pretreated with the methanolic extracts of Limnophilla indica for one week and then challenged with CCl4 (1.5 ml/kg) in olive oil (1:1, v/v). Serum marker enzymes (ALP, AST, ALT and Total bilirubin) were estimated in all the study groups. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and Total bilirubin were tested in both toxic treated and extract treated groups. The result of the present study indicates that the plant extract showed a significant decrease in the serum levels of ALP, AST, ALT and Total bilirubin. These biochemical observations were supported by histopathological study of liver sections. This study confirmed the hepatoprotective property of these plants as they were used in traditional medicine.
