The objective of this study was to investigate the hepatoprotective activity of methanol extract of leaves of Cayratia carnosa (Mecc) against lead acetate induced hepatotoxicity. The material was shade dried; they were powdered and extracted with methanol. The hepatoprotective activity of methanol extract was assessed in lead acetate induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like ALT, AST, ALP, ACP and LDH and serum parameters like Cholesterol, triglycerides and bilirubin were tested in both lead acetate treated and untreated groups. Lead acetate induced group has enhanced the ALT, AST, ALP, ACP and LDH and serum parameters like Cholesterol, triglycerides and bilirubin in liver. Treatment with methanolic extract of Cayratia carnosa leaves (250 mg/kg/bwt) has brought back the alerted levels of biochemical markers to near normal levels in the dose dependent manner. Our findings suggested that methanol leaf extract of Cayratia carnosa possessed hepato protective activity.
