In litreture plant Bassia latifolia is widely mentioned for its uses in ulcers, fractures, bronchitis, ear complaints, expelling worms from the body and in orchitis. To evaluate the hepatoprotective activity of alcoholic and aqueous extracts of bark of Bassia latifolia (AEBBL and AQEBBL) (Sapotaceae) in PCM induced hepatotoxicity in rats.Hepatoprotective activity of the AEBBL and AQEBBL was evaluated against PCM (curative aspect) induced hepatotoxicity model in rats, Standard drug like Silymarin was used as reference in each model.Preliminary phytochemical studies with AEBBL and AQEBBL revealed the presence of phytoconstituents like glycosides, tanins, saponins, triterpenoids and flavonoids in both the extracts. When this extracts is subjected for LD50 studies, produced abnormal behaviour or mortality even at the dose level of 2000 mg/Kg body weight in mice. Three different doses like low 1/20th (100 mg/Kg), medium 1/10th (200 mg/Kg) and high 1/5th (400 mg/Kg) doses from the maximum dose tested for LD50 were selected for the present study.Silymarin, AEBBL and AQEBBL treated groups when compared to PCM (curative aspect) induced hepatotoxic rats the increased TST, wet liver weight and wet liver volume, ALT, AST, ALP, BILD, BILT, CHO and TG levels were significantly reduced and ALB and PRO levels were significantly increased. The histopathological changes i.e. fatty changes (steatosis), necrosis etc were partly or fully prevented. The present study on hepatoprotective activity with AEBBL and AQEBBL confirmed the above mentioned effect because of several phytoconstituents like triterpenoids and flavonoids as these were already reported for their hepatoprotective activity.
