This study investigated the effects of Caulis bambusae stem extract on haematological and biochemical parameters rabbits to ascertain possible toxicity. Twelve aged matched healthy adult male chinchilla rabbits (1.80 ± 0.05–2.0 ± 0.11kg body weight) were divided into three groups. Group 1 was given distilled water in addition to normal feed and served as the control. Groups 2 and 3 were treated with 2.5 and 5ml of aqueoue extract of Caulis bambusae by oral intubation. Treatment lasted 90 days with blood collected on days 30, 60.And 90 for analysis. Results obtained revealed no significant difference (P>0.05) in red blood cells (RBC), haemoglobin (Hb), Packed cell volume (PCV), Mean corpuscular volume (MCV), Mean corpuscular haemoglobin (MCH) and Platelets counts between the treatment groups and control. White blood cell count was significantly (P<0.05) elevated in treatment groups. Glucose, Protein, Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphotase (ALP) and Acid phosphotase (ACP) levels were also not significantly affected (P>0.05) when compared to the control. Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C) and Low density lipoprotein cholesterol (LDL-C) were however significantly decreased (P<0.05) in the treatment groups. The results suggest thatCaulis bambusae stem extract has no adverse effect on the haematological and biochemical profile of treated experimental animals but showed evidence of hypolipidaemic activity which could be of value in the management of cardiovascular problems.
