Purslane is an annual succulent in the family Portulacaceae. The aim of this study was to overview therapeutic effects of Purslane .This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases .The initial search strategy identified about 96 references. In this study,63 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Purslane and dated mainly from the year 1993 to 2016.The search terms were “Purslane”, “therapeutic properties”, “pharmacological effects”. Purslane possesses the relaxant properties, Antioxidant effect, Anti-inflammatory effect, antitumor effect, Cytoprotective effect, Homogenizing effect, Anti-fungal effect, Neuroprotective Effect, Antibacterial Activity, Hepatoprotective effects, Bronchodilatory effect. Purslane was shown to be very useful for its pharmacological activity besides, medicinal properties of its extract require more clinical trial studies about the other practical and hidden activities of this plant.