Isoxazole derivatives possess antibacterial, antiviral, anti-fungal, anti-inflammatory insecticidal activities. The novel series of isoxazole carboxamide derivatives were prepared by the various ketene dithioacetals condensed with hydroxyl amine hydrochloride, potassium hydroxide under microwave irradiation. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their antibacterial and antifungal activity in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal strains. The biological activities of the synthesized compounds have been compared with standard drugs Streptomycin and Greseofulvin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis antimicrobial and antiinflammatory screening of the new compounds are reported.
