Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of TBAB as catalyst. These reactions were performed under solvent free conditions with microwave irradiation as the energy source. This new method has the advantage of excellent yields (90–95%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and ecofriendly preparation.
