The hydrophobicity and limited bioavailability of both drug Curcumin and TiO2 nanoparticles is destroyed herein this work by coating the anatase TiO2 nanoparticles with biodegradable polymer Chitosan. TiO2 nanocarriers for drug Curcumin had been synthesized by simple wet chemical co precipitation route and the nanoparticles functionalized in biological fluids by capping with Chitosan. The synthesized nanomaterials were characterized by UV-VIS, IR and XRD spectroscopic analysis. The morphology and particle sizes were determined on the basis of XRD. The primary biological activities of functionalized TiO2 loaded with Curcumin were tested on Shiegella bacteria for antibacterial analysis. These functionalized TiO2 nanoparticles exhibited higher antibacterial activities at MIC 1μg/ml. compared to free hydrophobic TiO2 and drug Curcumin and shown particle size of 24 nm. and Spherical Morphology with anatase core. This work resulted in a simple drug delivery system of TiO2 for future applications in delivery of hydrophobic drugs to biological systems for antibacterial and anticancer trials.
