Oral disintegrating tablets are a class of novel solid dosage forms, which immediately disintegrate into fine particles upon contact with water to aid the rapid dissolution of the active pharmaceutical ingredient placed in it. Amlodipine is a calcium channel blocking agent used mainly in the treatment of hypertension and angina. Hypertension and angina are the disorders associated with heart, which require immediate therapy. So, the dosage form administered should produce the pharmacological action immediately. In order to improve the rate of dissolution and there by absorption, to elicit the quick pharmacological action, preparation of oral disintegrating tablets (ODTs) by co – grinding technique is an excellent approach. In this present research work, we explored three different super – disintegrants in the preparation of Amlodipine ODTs. Poly vinyl pyrrolidone (PVP) was employed in order to improve the mechanical strength of the tablets and sodium lauryl sulphate (SLS) (highly water soluble agent) was employed instead of magnesium stearate as lubricant. The Amlodipine ODTs prepared with croscarmellose sodium without PVP and SLS (formulation F6) were disintegrated in 22 sec and dissolved completely within 15 min., and proved promising among the developed 9 formulations. The effect of pH of SLS on the drug dissolution rate from the ODTs was studied and found unique.
