In the present study an attempt was made to prepare alginate floating microparticles by ionotropic gelation method with calcium carbonate (CaCO3) 1% w/v in gelation medium used as gas-forming agent for oral delivery of Ofloxacin. Chitosan was used to enhance the drug encapsulation efficiency. Various physiochemical properties such as particle size, shape, in vitro buoyancy and drug release was compared with with non-floating microparticles. Data indicate that gas bubbles form cavities in tha particles which may attributed to enhanced in vitro buoyancy and fast release of Ofloxacin from floating microparticles.
