Der Pharmacia Lettre
Abstract
Author(s): Swapnil umakant wani, Prashant Shamkuwar, Ashwini Nagnath Yerawar, Ramandeepsingh Bedi
The purpose of this research was to formulate tasteless complexes of Fexofenadin Hydrochloride
with Doshion P547 and to evaluate different factor affecting Drug-Resin Complexation wise,
effect of batch and column process, complexation time, temperature, and pH on Fexofenadin
Hydrochloride loading on Doshion P547 is reported. Drug resin complexes (DRC) were
characterized by infrared spectroscopy, thermal analysis. Fexofenadin Hydrochloride release
from DRC is obtained at salivary and gastric pH. The efficient drug loading was evident in batch
process using activated Doshion P547 with a drug-resin ratio of 1:3. Drug complexation
enhanced with pH from 1.2 to 5, while temperature did not affect the complexation process.
Infrared spectroscopy revealed complexation of Ã?¢Ã?â?¬Ã?â??NH (drug) with Doshion P547. Drug release
from DRC in salivary pH was insufficient to impart bitter taste. Complete drug release was
observed at gastric pH in 2 hours. Doshion P547 is inexpensive, and the simple technique is
effective for bitterness masking of Fexofenadin Hydrochloride.
