To achieve successful delivery of drug locally as well as systematically, rectal route has proved its potential. The main objective of this research work was to formulate and evaluate herbal extract Aloe Vera suppositories. Suppositories are inserted directly into the rectum to distribute their herbal powder to internal areas. Aloe Vera contains aloin, which is an anthraquinones glycoside. Aloin has been used as a laxative for constipation. It showed laxative action. Extract of Aloe Vera was done by soxhlet using methanol as solvent. Heat molding method was used for the preparation of suppositories, which were evaluated for their physicochemical properties and in-vitro release characteristics. Suppositories of polyethylene glycol (PEG) 4000 and surfactant showed better permeation of drug and laxative action.
