Der Pharmacia Lettre
Abstract
Author(s): Venkata Ramana Reddy S, Sathyanarayana Dondeti,
Manavalan R, Sreekanth J
The aim of the present investigation was to develop simple oral disintegrating tablets (ODT) for
industrial purpose with different category of drugs like granisetron hydrochloride, memantine
hydrochloride, amlodipine besylate, desloratadine, zaleplon and risperidone using different
formulation and process. Granisetron hydrochloride (GRN), memantine hydrochloride (MEM),
amlodipine besylate (AML) and zaleplon (ZAL) drugs are low bitter and low dose drugs. ODT of
these drugs were prepared to using direct compression tablets techniques with simple taste and
flavors enhancers. ODT of desloratadine (DES) and risperidone (RIS) were prepared using wet
granulation tablets technique with different taste masking agents, taste and flavor enhancers,
because these two drugs are highly bitter with low dose drugs. Simple taste and flavor enhancers
were not sufficient to mask bitterness of these drugs. Amberlite was used as a taste masking
agent, Mannitol was used as a diluents, Acesulfame potassium, aspartame and peppermint was
used as a flavoring agent. The results revealed that the tablets containing taste masking had a
good palatability for the patients. It was concluded that all the ODT�¢����s with improved taste
masking and dissolution could be prepared by simple compressed tablet technique with suitable
excipients. This work helped in understanding the effect of oral disintegrating tablets
formulation and processing comparison of compressed tablet technique, especially the
disintegrating and taste masking agents on the drug taste masking, disintegration time and
release profile. The present study demonstrated potentials for rapid disintegration in oral cavity
with out water, improved taste masking and patient compliance
