Der Pharmacia Lettre
Abstract
Author(s): Manish K Singh, Vikas Chandel, Vandana Gupta and Suman Ramteke
In the present work glipizide based microemulsion was developed and its usefulness as topical
drug carrier system for the non-insulin dependent diabetes mellitus (NIDDM) was investigated.
Microemulsion was prepared by water titration method using oleic acid as oil phase, tween-80
as surfactant and propylene glycol as co-surfactant. Menthol as a permeation enhancer was
added to a final drug-loaded microemulsion formulation at the level of 1% w/w. Microemulsions
were characterized for pseudo-ternary phase diagrams, pH, viscosity, droplet size, in vitro
release profile, ex-vivo diffusion study, irritancy tests, stability and in vivo evaluation. The
optimized microemulsion formulation was found to be o/w type emulsion by pseudo ternary
phase diagram and having mean particle size of 138Ã?â??Ã?±4.5 nm. The results indicated that the
developed microemulsion systems, especially ME-3, may be promising vehicles for the
transdermal delivery of glipizide. In vivo studies were carried out on wistar rats and the samples
were analyzed for glucose content by Accu-check blood glucose meter. Inclusion complex
showed significant blood glucose reduction as compared to drug alone. Microemulsion system
provides viscous consistency for the topical application, which delivered the drug in sustained or
controlled manner and prolonged delivery as compared to conventional dosage form.
