The main objective of this work was toinvestigate the possibility of obtaining a sustained release formulation of ibuprofen microspheres by using ethylcellulose in various drugs, polymer ratios (1:2, 1:1, 2:1).Microspheres are the novel drug delivery system (NDDS) as a controlled release dosage form to maintain relatively constant drug level in the plasma by releasing the drug at a predetermined rate for an extended period of time. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAIDS) was formulated as microspheres by using ethylcellulose as carrier. These ethylcellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation and invitro release studies. Highest percentage of loading was obtained by increasing the amount of ibuprofen with respect to polymer. The particle sizes of the prepared microspheres were determined by optical microscopy. The invitro release studies showed that ibuprofen microspheres of 1:2 ratios hadbetter sustained effect over a period of 10 hours.
