The present research was aimed to develop sustained release mini tablets of Pregabalin by direct compression method. These were prepared by using chitosan, locust bean gum, microcrystalline cellulose (MCC), Xanthan gum, polyvinyl pyrrolidine K-30 (PVP K30). The precompression parameters like angle of repose, bulk density, true density, Carr’s index, Hausner’s ratio and post compression parameters like thickness, hardness test, friability and weight variation, drug content uniformity were evaluated and the results were lies within the limits. In-vitro dissolution study was performed by using 0.1 N HCl for first 2 h and it was replaced by pH 6.8 phosphate buffer for further study. It was found from the results that the formulation F6 showed sustained release of 12 h and followed zero order kinetics with non fickian mechanism.
