The main purpose of present investigation is to extend the release of drug from the dosage form at a particular site and controlling the release of drug from the dosage form and achieving controlled plasma level of the drug as well as improving bioavailability. The study was performed by selecting Glimepiride and Parecoxib drugs. The mucoadhesive tablets were prepared to achieve controlled plasma level of the drug which is especially in diabetes mellitus patients with pain therapy. The tablets were prepared by direct compression technique. Both the drugs were found compatible with the excipient used. All the formulations were found to have good pre compression and post compression parameters. The optimized formulation was subjected to accelerated stability studies.
