The main aim of this investigation was to develop gastroretentive beads for controlled release of the drug for the treatment of H.pylori infections more efficiently by releasing the drug especially in stomach for a prolonged duration of time. Floating mucoadhesive beads were prepared to prolong the gastric retention of the drug. Floating mucoadhesive alginate - hydroxypropyl methylcellulose beads of Levofloxacin hemihydrate were prepared by using emulsion gelation method. The interactions between drug and polymers were investigated by Fourier transform infrared (FTIR) Spectroscopy and Differential scanning calorimetry (DSC). Prepared beads were evaluated for particle size, entrapment efficiency, and surface morphology by using scanning electron microscopy. In vitro drug release studies were carried out. According to FTIR and DSC, the drug did not show any evidence of an interaction with the polymers used. From the in vitro drug release studies, the drug release from formulation F6 was found to be 71.68 % and showed controlled release. From the results it can concluded that F6 formulation was found to be better than the other formulations, as it showed controlled drug release. Hence it may achieve the aim of controlling the drug release, prolong retention time in GIT and reduce the frequency of dosing.
