Der Pharmacia Lettre
Abstract
Author(s): Karthikeyan.J, S.Janardhan, N.Saravanakumar, S.Selvaraj,
R.Sivasakthi, R.Mennakumari
The objective of the present study was to microencapsulate the Anti-Hypertensive drug
(treatment of several disease of Cardio Vascular System, especially Hypertension.) Metoprolol
Tartarte to provide Sustain Release and maintain constant the plasma drug concentration and
reduce the frequent administration and improve the Patient compliance, unwanted side effects
and Dose dumping. Metoprolol was microencapsulated with Eudragit-RS100 using solvent
evaporation techniques. The effect of different 6 Formulation variables including the drug
polymer ratio. Metoprolol Microspheres was subjected to micrometritic properties including
Angle of Repose, Bulk density, Carr�¢����s index, Haugner�¢����s ratio and Particle size determination.
Metoprolol Microspheres was subjected to Drug Loading, invitro drug release as well as for
Scanning electron microscope and kinetic drug release.
