Der Pharmacia Lettre
Abstract
Author(s): Suresh Bandari, Krishna Sanka, Raju Jukanti, Prabhakar Reddy Veerareddy
The aim of the present investigation was to develop colon specific double cross linked alginatechitosan
blend gel beads for pulsatile release. A 32 factorial design was employed to study the
influence of two independent variables amount of piroxicam (X1), amount of chitosan (X2) on
dependent variables, encapsulation efficacy (YEE), amount of drug release at 5th hour (Y5) and
amount of drug release at 6th hour (Y6). The prepared colon specific pulsatile beads were
evaluated for particle size and invitro drug release studies. Drug polymer interaction studies
were determined by fourier transform infrared (FTIR) spectroscopy. The surface characteristics
and morphology was determined by scanning electron microscopy (SEM). The check point batch
was prepared and the contour and 3D plots were also presented. It was concluded that the
desired colon specific pulsatile release was obtained with alginate-chitosan blend gel double
cross linked beads.
