The Metformin HCL Micro Beads is formulated by the Ionotropic Gelation Method. The CMC is a Swellable polymer is responsible for the Sustained release action or activity. A combination of CMC (Carboxy Methyl Cellulose) and Sodium Alginate shows better sustained release activity. The PreparedSustained released Micro Beadsis Evaluated In terms of bulk density, tapped density, angle of repose, Carr’s Index, Swelling Index, Drug Content, % Encapsulation Efficiency and vitro study. The result associated in Optimized batch is good to Satisfactory and having a good free flowing property. The Drug Content and % Encapsulation Efficiency values are within the pharmacopeia limit. The in vitro Dissolution studies shows Maximum percentage of release of drug (71.15) with in end of 4 Hours.
