Der Pharmacia Lettre
Abstract
Author(s): Saraswathi R, Krishnan.P.N, Dilip.C, Shabir Ali T.K
An attempt was made to formulate and evaluate the curcumin transdermal drug delivery system.
Preformulation studies on the drug curcumin were done which included description, solubility
and compatibility studies. The transdermal patches were made which were of matrix diffusion
control system. Solvent casting technique was used to prepare the transdermal patches. Three
formulations were made with 20mg of curcumin and by using polymers namely hydoxy propyl
methyl cellulose, ethyl cellulose at various ratios and the yield was noted. Curcumin was
physically examined for color and odour. Solubility was determined in water, phosphate buffer
pH -7.4, Ethanol, DMSO and Tetra hydro furan. Interaction of drug and polymer was confirmed
by UV Ã?¢Ã?â?¬Ã?â?? Visible interaction and FTIR studies. Based on this further evaluation was carried
out.Invitro drug diffusion stuy was also carried out using modified Franz diffusion cell.
Transdermal patches were evaluated for the weight, thickness, percentage moisture uptake,
percentage flatness, folding endurance, water vapor transmission rate, and in-vitro release
studies. This was done for three formulations F1, F2, F3. It was found that formulation F1
showed the best compatibility on the basis of all tests performed.
