The objective of the present work is to mask the intensely bitter taste of Roxithromycin and to formulate an FDT of the taste-masked drug by incorporation of Excipients in the tablets. Method of Roxithromycin was prepared by solvent evaporation method using methanol as solvent for pH-sensitive polymer: act as the encapsulating medium. The Mixture of Roxithromycin with PEG 6000 indicates highest increase in solubility with 3.7-folds Roxithromycin and PEG 6000 (1:2SD) were selected as optimized combinations for Roxithromycin. The optimized combinations was formulated into Fast dissolving tablet. The optimized combinations were subjected to FT-IR and while dissolution, and accelerated stability studies were performed on their formulations. The physical properties were evaluated with regard to yield, drug content, flow properties, particle size, in vitro drug release and taste. The average size of microspheres was found to be satisfactory in terms of the size and size distribution. The FDTs prepared by direct compression method and evaluated for hardness, thickness, weight variation, friability, disintegration time, drug content, wetting time, in vitro disintegration, in vitro drug release and stability. Result and discussion simulated salivary fluid (pH 6.8) and sufficient flow properties was shown in the drug: polymer ratio
