Sustained release tablets of isoniazid were fabricated using guar gum and carbapol, Tragacanth Gum and PEG-6000, in different proportion and combinations by direct compression technique, Bulk density, tapped density, compressibility index, Hausner ratio before being punched as tablets. The tablets were evaluated for physical characteristic like hardness, weight variation, friability, and drug content. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and or standard references. Results of in vitro release profile indicated that formulation (F2) was the most promising formulation as the extent of drug release from this formulation was high as compared to other formulations. From the above results and discussion it is concluded that formulation of sustained release tablet of Isoniazid containing Guar gum (1.5%), Batch F2 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hour release as it fulfills all the requirements for sustained release tablet.
