Der Pharmacia Lettre
Abstract
Author(s): N.L Prasanthi, N. Rama Rao, S.S.Manikiran
The aim of the study was to formulate and evaluate solid binary systems of the poorly watersoluble
novel antipsychotic drug ziprasidone hydrochloride. The solid binary systems were
prepared by using a new carrier (modified starch such as starch phosphate) for improving the
dissolution properties. Starch phosphate was prepared by a reported method. The solid binary
systems were prepared by kneading method in different drug to carrier molar ratios (1:1, 1:3,
1:9 and 1:19). Evaluation of the solid binary system was performed using dissolution studies,
Differential thermal analysis, Infrared Spectroscopy and X-ray powder diffraction studies. All
the solid binary systems showed dissolution improvement when compare to pure drug and
physical mixture to varying degrees, binary systems prepared by kneading method in 1:9 drug to
carrier ratio exhibited the highest drug release. Mathematical modeling of in vitro dissolution
data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics
primarily as Fickian diffusion.
