Poor aqueous solubility always has been a very challenging obstacle like Simvastatin needs to be enhanced by using Powder solution technology. The present research proving the Propylene glycol, Avicel PH 101 and Aerosil PH 200 suitable for the liquisolid tablets i.e. resulting highest dissolution rate due to the wettability , producing of the super saturated microenvironment around the tablets and good flow properties by changing the 5:1 to 10:1 excipient ratio ( R ). All Simvastatin liquisolid tablets were showing the highest dissolution rate (99.9%) within the 60 minutes comparison with the direct compressed tablets and marketed tablets.
