The objective of the present investigation was to prepare buccal films for rifampicin by using liposomes as carriers. Liposomes have physical instability issues caused by aggregation of vesicles to form large particles. To overcome the stability problems and improve the oral bioavailability, rifampicin was formulated as liposomes and further they were formulated into films. Liposomes were prepared by solvent injection method using lecithin, and cholesterol. The liposomes were evaluated for their physical and chemical properties. The liposomes that were formulated were again made into buccal films using HydroxyPropyl Methyl Cellulose (HPMC) 15cps as a film former and propylene glycol used as a plasticizer by simple solvent casting technique. These dosage forms were characterized for their physicochemical properties by using FTIR, XRD, SEM etc. They were further evaluated for drug content and in vitro drug release. The drug release from the films was uniform and complete. More than 90 % of the drug released from all the films within 60 minute. Data of in vitro release from films were fit to different kinetic models to explain release profiles. Kinetic models used were zero order, first-order, Higuchi and Korsemeyer-Peppas. The drug release decreased with increasing the polymer concentration. The drug release from the films followed zero order anomalous behavior (Non-Fickian). The present study clearly indicted the usefulness of liposomal films for administration rifampicin through buccal route.
