Oral films are the newer technologies in the manufacturing of orally disintegrating dosage forms. They are thin and elegant usually made of edible water-soluble polymers of various sizes and shapes like square, rectangle or disc. The strips may be flexible or brittle, opaque or transparent. They are designed to provide rapid disintegration on the tongue without the need for water. This work investigated the possibility of developing Zolmitriptan fast dissolving strips allowing fast, reproducible drug dissolution in the oral cavity, and thus decreasing the migraine effect in patients in less time and enhancing the patient compliance. All the formulations were prepared with HPMC 5cps, Propylene glycol, Acesulfame potassium, peppermint flavor. The dissolution of the film samples evaluated gave maximum release within 12 minutes indicating the rapid drug release profile which entails in faster onset of action for the medicament.
