The poor aqueous solubility of the drug results in variable dissolution profile and hence poor bioavailability. The aim of present work was to show the effect of various super disintegrants on the disintegration time and in vitro drug release rate. In this study, an attempt has been made to prepare rapid disintegrating tablets of the drug using different super disintegrants following wet granulation method. The Tablets were formulated by wet granulation method, using Mannitol as diluent. Crospovidone (XL-PVP) (6 and 8%), croscarmellose sodium (Ac-Di-Sol®) (6 and 8%), Sodium starch glycolate (6and8%) were used as super disintegrants at different concentrations. The Precompression parameters like bulk density, tapped density, Carr’s Index and angle of repose were determined. The post compression parameters like the hardness, thickness, friability, weight variation, Disintegration time, invitro dissolution, FT-IR studies were carried out to check whether any interaction had occurred, results were promising. HPLC method was used to find out the percentage drug content and was found to be 99.6%.The optimized formulation was selected based on the results and stability studies were carried out on the optimized formulation and the percentage drug release was found to be 97.8%.
