The purpose of present investigation was used to develop and evaluate orodispersible tablets of lafutidine, because it is used in patients recurrently suffered from peptic ulcer, ant it is used as a pre-anaesthetic medication, fast onset of action and avoidance of water is highly desirable. Tablets were prepared by direct compression by using three superdisintegrants of sodium starch glycolate ,crospovidone and Croscarmellose Sodium were used alone as well as in combination . The combination of superdisintegrants gave better disintegration effect. Micro crystalline cellulose was used as diluent, mannitol and aspartame were used to enhance the organoleptic properties of tablets. The dissolution studies were conducted in 900 ml of pH 6.8 phosphate buffer. The optimized formulation F-12 showed good release profile with maximum drug release at all time intervals. The drugs with other excipients were interaction evaluated by FTIR. FTIR spectrum of pure drug was compared with other formulations. All peaks corresponding to the different functional groups of the pure drug were present in the formulations which indicate the absence of interaction between the drug and excipients. The selected formulation F-12 was subjected for stability studies as per ICH guidelines. Formulations subjected for stability studies were checked for drug content, hardness, friability and physical appearance for 90 days with an interval of 15 days. The formulations were found to be stable as no significant change was observed in the various evaluated parameters of the formulations. It was concluded that orodispersible tablets of Lafutidine could be prepared by using blend of all three superdisintegrants. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
