The present study was aimed towards the formulation and in vitro evaluation of orodispersible tablets by direct compression method using Risperidone as a model drug to enhance patient compliance. Orodispersible tablet of Risperidone was prepared by masking the bitter taste by cetyl alcohol using different ratios of drug with cetyl alcohol (2:1). Here crosspovidone and sodium starch glycolate in different concentrations (2%, 4%, 6% and 8%) are used as superdisintegrant. All the batches were prepared by direct compression method. Prepared tablets were evaluated for weight variation, hardness, friability, in vitro disintegration time, in vivo disintegration time, dispersion time, thickness, drug content and dissolution study. By considering disintegration time and concentration of superdisintegrant, formulation with drug to cetyl alcohol concentration (2:1) and crosspovidone 4% was optimised. Optimised tablet formulation was subjected to stability studies for three months at room temperature and 400 c/ 75% RH.
