The purpose of the present research was to optimize the formulation of Orodispersible tablets of Levocetrizine. Orodispersible tablets of Levocetrizine were prepared by Melt Granulation Technology. The formulations were evaluated for Tablet weight variation, content uniformity, hardness, friability, wetting time, dispersion time, drug content and in vitro release also have been studied. All formulations showed satisfactory mechanical strength and tablets containing Crospovidone (10%) showed excellent in vitro dispersion time and drug release as compared to other formulations. The results revealed that the tablets containing 10% Crospovidone (F8) showed short dispersion time (12 sec) with maximum drug release (100%) in 20 min. FTIR & DSC results showed no evidence of interaction between the drug and polymers. This study helps in revealing the effect of formulation processing variables on tablet properties. It can be concluded that the Orodispersible tablets of Levocetrizine tablets could be prepared by Melt Granulation Technology using Crospovidone as superdisintegrant.
