The present study aims to formulate and evaluate oral disintergrating tablet of nateglinide, a drug that is used for the treatment of non-insulin dependent diabetes milletus was prepared by using different polymers and also optimize the best formulation. The study involved different excipents which were tested for their compatibility with nateglinide by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with nateglinide which were used for the preparation of nateglinide oral disintegrating tablets. nateglinide is an oral anti-diabetic agent agent used for the treatment of non-insulin dependent diabetes milletus. Oral disintegrating tablets of of nateglinide were prepared by direct compression method by the addition of superdisintegrants. Nine batches (F1-F9) of oral disintegrating tablets of nateglinide were prepared by using superdisintegrants like Crosspovidone, Croscromellose Sodium and Sodium starch glycolate in variable concentrations along with other excipents for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, in-vitro disintegration, invitro- dissolution studies and are found to be within the limits.
