In this study, we prepare microspheres containing Nigella Sativa and Olive oil by spray drying method and these microspheres were added to carbopol gel. Spray dried microspheres added to Carbopol gel were evaluated for surface morphology and showed to be shriveled, In-vitro release studies showed 90.15 % and 98.34 % releases for NSSOM and NSSOMgel, release kinetics showed that the drug release followed First Order (R2 =0.9826) and Korsmeyer’s Peppas (R2 = 0.9950) respectably. During storage at 3-50C or room temperature (15-250C) for 12 months, surface morphology and content of Nigella Sativa and Olive oil had no notable changes. The conventional commercial preparations, such as creams, foams, gels, irrigations and tablets have limitations such as leakage, messiness and low residence time; often require multiple daily doses to ensure the desired therapeutic effect and which contribute to poor subject or patient compliance. Attempts have been made to develop microspheres mucoadhesive vaginal gel that can meet the clinical as well as the user’s requirements.
