Among modified-release oral dosage form increasing interest has currently turned to systems designed to achieve prolonged retention at the site of drug delivery. Amongst them, mucoadhesive microspheres offer better retention and controlled release. To overcome inherent drawbacks associated with conventional dosage forms of Flurbiprofen, an attempt was made to develop an alternative drug delivery system in the form of mucoadhesive microspheres. The objective of the present study was to formulate and evaluate mucoadhesive microspheres of Flurbiprofen. In the present study, 6 formulations (F1, F2, F3, F4, F5, F6) with variable concentrations of polymers (Sodium CMC, Carbopol & HPMC) were formulated and evaluated for physico-chemical, preformulation and formulation parameters, in vitro release studies and results obtained in in vitro release studies were plotted in different models of data treatment. Compatibility studies by FTIR proved that there was no interaction between Flurbiprofen and the polymers used. The mean particle size of microspheres of each batch ranged between 289.43 to 387.75 μm which ensured good handling characteristics of all batches. The percentage drug entrapment efficiency of all formulations was found to be between 86.94% and 92.06%. The percentage drug loading of all the formulations were found to be between 19.56% and 21.35%. All the six batches were subjected to in vitro release studies with 0.1 N HCl (pH 1.2) and phosphate buffer pH 7.4. All the formulations had shown adequate release of the drug, however, the optimum release was observed with formulation F1
