Mucoadhesive polymer owing to its binding capacity with gastric mucin prolongs the gastricresidence time and thereby increases bioavailability. In the present research work an attempt was made to formulate and evaluate mucoadhesive matrix tablets of carvedilol. Matrix tablets were prepared by direct compression technology using different types and levels of polymers viz. HPMC 100M,HPMC E5, etc alone and in combinations. Compressed tablets were evaluated for thickness, friability, hardness, uniformity of weight, and in vitro dissolution studies. These studies indicates that the drug release can be modulated by varying the concentrations of polymers. It was observed that combination of both the polymers in equal concentrations exhibits the best release profile and able to sustain the drug release for 10hrs. Formulataion F11 shows the optimum mucoadhesive strength with drug release when compared to all other formulations in the test. Stability studies revealed that all the formulations was found to be stable under accelerated stability studies.
